Aetiology of disease

Aetiology is a term describes about the cause of disease. Pathogenesis is solely concerned with the origin of disease. In both of the common types of diabetes, environmental factors interact with genetic susceptibility to determine, which people develop the clinical syndrome, and the timing of its onset. However, the underlying genes, precipitating environmental factors and pathophysiology differ substantially between type 1 and type 2diabetes. mantle clocks Type 1 diabetes was previously termed ‘insulin-dependent diabetes mellitus’ (IDDM) and is invariably associated with profound insulin deficiency requiring replacement therapy. Type 2 diabetes was previously termed ‘non-insulin-dependent diabetes mellitus’ (NIDDM) because patients retain the capacity to secrete some insulin but exhibit impaired sensitivity to insulin (insulin resistance) and can usually be treated without insulin replacement therapy.